Relationship of cardiac output and heart rate

relationship of cardiac output and heart rate

The cardiac output is simply the amount of blood pumped by the heart per minute . Necessarily, the cardiac output is the product of the heart rate, which is the. The heart rate is perhaps the simplest determinant of cardiac output to visualize: . relationship to increase stroke volume and cardiac output. when cardiac output did not increase, mean arterial pressure also remained unchanged. .. the stroke volume/heart rate relationship have been done in.

But in various other organs, norepinephrine and epinephrine do not produce the same actions.

Relationship between the changes in heart rate and cardiac output during the Valsalva maneuver.

Regulation of the Stroke Volume Sympathetic Effect Autonomic nerves not only innervate the SA node, but also are found elsewhere in the heart. This tends to be significant mainly at the greatest levels of exercise. For example, the ventricle of a 70 kg person at rest might hold about ml of blood at the end of diastole. As noted above, a typical stroke volume is about 70 ml. This is the fraction of the blood in the ventricle that is ejected during systole.

relationship of cardiac output and heart rate

Norepinephrine, by increasing the force of contraction, would tend to increase the ejection fraction and thus the stroke volume. Afterload The aortic pressure influences the stroke volume for a straightforward reason. If the aortic pressure increases, this pressure reduces the volume of blood that flows into the aorta during systole. The aortic pressure is called afterload because it is the "load" experienced by the ventricle after it begins contracting.

relationship of cardiac output and heart rate

A drug might reduce the afterload, for example, by dilating arterioles. This allows blood to flow from the arteries more easily, thereby preventing the arterial pressure from increasing as blood is injected into it by the ventricle.

Frank-Starling Mechanism However, the factor we will be most concerned with is the Frank-Starling mechanism. Unfortunately, it is also the one most difficult to get your mind around.

Cardiac Output

The Frank-Starling mechanism leads to changes in the stroke volume as a result of changes in the end-diastolic volume. The end-diastolic volume is the volume of a ventricle at the very end of filling and just before systole begins. This can change because the ventricles are flexible and under different circumstances, the amount of blood flowing in during diastole varies.

If less blood flows into the ventricle as it fills, the end-diastolic volume goes down. If more blood flows in, the end-diastolic volume goes up. The Frank-Starling effect is due to the fact that heart muscle fibers respond to stretch by contracting more forcefully. This is not a passive, elastic effect, but rather due to an increased expenditure of ATP energy. We are not going to try to explain the cellular basis of this effect. It is not as straightforward as you might think.

Thus, if the end-diastolic volume increases, the muscle fibers are lengthened and the ventricle contracts more forcefully, ejecting a greater stroke volume.

relationship of cardiac output and heart rate

The figure to the right shows this Frank-Starling effect. What factor alters the filling during diastole? For the right ventricle, this is the pressure in the right atrium, because this is the pressure that is experienced by the right ventricle as it fills. Since there is no valve at the entrance to the right atrium, the pressure in the right atrium is necessarily the same as the pressure in the veins at the entrance to the right atrium.

This pressure in the large veins at the entrance to the right atrium is called the central venous pressure. In other words, the central venous pressure is the same at the right atrial pressure, and this is the pressure that determines the filling of the right ventricle and thus its end-diastolic volume.

relationship of cardiac output and heart rate

The central venous pressure always is only a few mm Hg, but nonetheless it does change enough to significantly affect the stroke volume. In particular, posture changes this pressure and that is the factor with which we are here most concerned. The Effect of Posture on Stroke Volume Recall how voluminous and thin-walled the superior and inferior vena cava are.

You probably were able to put two fingers into the superior vena cava of the pig heart. When a person is lying down, the large veins in the chest are plump with blood. And because these veins are stretched, the pressure in them is higher than when they contain less blood. Consequently, when lying down, the central venous pressure is relatively high, the end-diastolic volume is relatively high and thus the stroke volume is comparatively high.

Stroke Volume and Cardiac Output

But this changes when we stand. Actual measurements are performed on heart patients by measuring arterial pressure. Estimated average stroke volume amounts range between 50 to 70ml at rest to to ml during cardio training. Elite athletes have estimated stroke volumes between 90 to ml at rest to to ml during cardio training. Cardiac Output Cardiac output is defined as the total amount of blood circulated throughout your body in one minute.

Cardiac output is measured by multiplying heart rate by stroke volume. Healthy individuals with higher cardiovascular fitness levels have lower heart rates, allowing a longer time for the heart to fill with blood.

The extra time for filling results in a higher stroke volume, or amount of blood that can be pumped in one beat. On the contrary, individuals with lower cardiovascular fitness levels have higher resting heart rates. This allows less time for your heart to fill with blood, lowering the amount of blood that can be pumped in one beat.

Understanding cardiac output

Improving Measurements Cardio training increases the demand on your heart and lungs to provide blood and oxygen to your body. Stoke volume and heart rate increase to meet the higher demands. Cardio workouts meeting suggested guidelines strengthen your heart and lung function, resulting in improved rates.