Pediatric medicines and their relationship to dental caries - Semantic Scholar
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- Are paediatric medicines risk factors for dental caries and dental erosion?
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Pediatric medicines and their relationship to dental caries
Many antibiotics presented high concentration of sugars, high titratable acidity, pH below the critical value and high viscosity which can be considered risk factors for dental caries and erosion, when consumed frequently. Sugars such as sucrose, fructose and glucose are added to increase bulk, palatability and, consequently, compliance [ 2 ]. These sugars are widely used because they are cheap, nonhygroscopic, and easy to process [ 3 ].
In addition, they may be used to improve flavor [ 4 ]. Because of these characteristics, various studies have pointed out the possible relationship between dental caries and frequent intake of liquid oral medicines [ 35 - 11 ]. The presence of sucrose in medicines leads to pH drop of dental plaque, and also acts as substrate for fermentation of oral microbiota, [ 12 ] contributing to dental caries. Moreover, these authors observed a correlation between an increase of S.
Liquid Oral Medication LOM becomes an additional source of sugars for chronically ill children on long term care.
Therefore, it becomes very essential that every health care professional who is involved with the prescription of medicine or drugs be aware of any consequential disorders that may arise as a side effect [ 16 ]. We designed the present study to test the hypothesis, formulated from clinical impressions that taking liquid medicine containing sucrose on a long term basis is a risk factor for dental caries.
The evidence for association between sugar based LOM and dental caries in children suffering from epilepsy is still deficient, therefore high quality clinical studies need to be conducted.Diet and Dental Caries in Children
Aim The present study was carried out with the aim to assess and compare the dental caries experience and its relationship with long term usage of LOM with those not under such medication among years old children with epilepsy. The study participants included patients visiting the hospital and suffering from epilepsy. Before scheduling the present study, the required ethical clearance which was obtained from the research review board of Jaipur Dental College to conduct the study and permission was taken from the concerned hospital authorities.
After taking the permission, detailed schedule was made and hospital authorities were informed in advance. A written informed consent was obtained from the parents of all children who were willing to participate in the survey. The research was conducted in full accordance with the World Medical Association Declaration of Helsinki. Based on the findings of the pilot study, a total of 84 chronically ill children among years under long term for more than three months LOM therapy were included as subjects of the study group in patients and in order to know the differences, a comparative group of children, who were newly diagnosed cases of epilepsy were included as control group [children visiting Out-Patient Department OPD ] for the first time.
Children aged years, suffering from epilepsy, receiving LOM for more than three months and those children whose parents gave the consent were included in the study.
The Journal of Pediatric Research
Study subjects who were not on long term oral liquid medications or on any other form of medication, those children whose parents did not give the consent and study subjects with medical disorders requiring major modifications to the carbohydrate content of their diet, such as diabetes mellitus and obesity and patients suffering from any other systemic disease were excluded from both groups.
The clinical examination for every subject was comprehensively carried out by single investigator. Prior to conducting the study, the investigator was calibrated at the Department of Public Health Dentistry, Jaipur Dental College, Jaipur, Rajasthan, India, in order to limit examiner variability and kappa value was found to be 0.
The same subjects were randomly examined on different days and the investigator repeated examinations on them. These values reflected high degree of conformity in observation. Pilot study and sample size calculation: