Aldosterone and renin relationship quotes

renin-angiotensin system | Definition & Facts |

aldosterone and renin relationship quotes

Renin is an enzyme that controls aldosterone production. Aldosterone and renin tests help diagnose primary (Conn syndrome) and secondary. The renin angiotensin system (RAS) and its effector molecule angiotensin Although the relationship between the RAS and the progression of. The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that regulates blood pressure and fluid balance.

As the name implies, there are three important components to this system: Renin is a proteolytic enzyme that is released into the circulation by the kidneys. Its release is stimulated by: Juxtaglomerular JG cells associated with the afferent arteriole entering the renal glomerulus are the primary site of renin storage and release. A reduction in afferent arteriole pressure causes the release of renin from the JG cells, whereas increased pressure inhibits renin release.

Renin-Angiotensin-Aldosterone System

Beta1-adrenoceptors located on the JG cells respond to sympathetic nerve stimulation by releasing renin. Aldosterone will make the kidneys do three things: Increases Potassium excretion; Potassium in the blood stream is excreted into the urine to be eliminated. That compensates for when your blood potassium level is too high one of the 3 original triggers!

It causes your kidneys to retain salt and compensate for low sodium levels. Instead of kidneys peeing out that salt, you retain it. Increase water retention which together with the increased salt retention, that causes your blood pressure to increase in your vessels. This is not like ADH. Here you retain both salt and water, so you are retaining isotonic fluid. The purpose of this is to expand your blood volume and by doing that, that raises your blood pressure, and that compensates for what initiated this reflex a drop in blood pressure.

If you increase the amount of water and salt retention, you will increase the blood pressure.

aldosterone and renin relationship quotes

How cool is that? One study in found ACE in all blood vessel endothelial cells. Angiotensin effects and Aldosterone function Renal hormone regulation schematic It is believed that angiotensin I may have some minor activity, but angiotensin II is the major bio-active product.

Angiotensin II has a variety of effects on the body: Throughout the body, angiotensin II is a potent vasoconstrictor of arterioles. In the kidneys, angiotensin II constricts glomerular arterioles, having a greater effect on efferent arterioles than afferent. As with most other capillary beds in the body, the constriction of afferent arterioles increases the arteriolar resistance, raising systemic arterial blood pressure and decreasing the blood flow.

aldosterone and renin relationship quotes

However, the kidneys must continue to filter enough blood despite this drop in blood flow, necessitating mechanisms to keep glomerular blood pressure up. To do this, angiotensin II constricts efferent arterioles, which forces blood to build up in the glomerulus, increasing glomerular pressure.

The glomerular filtration rate GFR is thus maintained, and blood filtration can continue despite lowered overall kidney blood flow.

The Renin Angiotensin Aldosterone Reflex

Because the filtration fraction has increased, there is less plasma fluid in the downstream peritubular capillaries. This in turn leads to a decreased hydrostatic pressure and increased oncotic pressure due to unfiltered plasma proteins in the peritubular capillaries. The effect of decreased hydrostatic pressure and increased oncotic pressure in the peritubular capillaries will facilitate increased reabsorption of tubular fluid. Angiotensin II decreases medullary blood flow through the vasa recta.

Renin-Angiotensin-Aldosterone System

This decreases the washout of NaCl and urea in the kidney medullary space.